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Fentanyl is a potent synthetic piperidine opioid primarily used as an analgesic. It is 50 times more potent than heroin and 100 times more potent than morphine; its primary clinical utility is in pain management for cancer patients and those recovering from painful surgeries. Duragesic is also used as a sedative. Wikipedia
Pronunciation: /ˈfɛntənɪl/ or /ˈfɛntənəl/
Metabolism: Liver, primarily by CYP3A4
Duration of action: 30–60 minutes
Onset of action: 5 minutes
Pregnancy category: AU: C
Excretion: Mostly urinary (metabolites, < 10% unchanged drug)
Formula: C₂₂H₂₈N₂O
This product is a potent synthetic opioid drug approved by the Food and Drug Administration for use as an analgesic (pain relief) and anesthetic.

What it is?

Pharmaceutical Duragesic is a synthetic opioid approved for treating severe pain, typically advanced cancer pain.1 It is 50 to 100 times more potent than morphine. It is prescribed in the form of transdermal patches or lozenges and can be diverted for misuse and abuse in the United States.

However, most recent cases of this med-related harm, overdose, and death in the U.S. are linked to illegally made Med &  it is sold through illegal drug markets for its heroin-like effect. It is often mixed with heroin and/or cocaine as a combination product—with or without the user’s knowledge—to increase its euphoric effects.

Signs of a  Overdose
>Small, constricted “pinpoint pupils”
>Falling asleep or losing consciousness
>Slow, weak, or no breathing
>Choking or gurgling sounds
>Limp body
>Cold, clammy, and/or discolored skin

How to Respond to a Suspected Overdose

Call 911 immediately.
Administer naloxone if available.
Try to keep the victim awake and breathing.
Lay the victim on their side.
Stay with the victim until emergency workers arrive.

Opioids | Fentanil | Fentanyl

  • illegal drug labs
  • patches that have been sold by or stolen from people they were prescribed to.

What does it look like?

Most street in Canada is produced illegally as a powder. Street may be swallowed, smoked, snorted or injected. It is released from prescription patches by smoking or chewing.

Duragesic is sold as a powder or a pill, or is cut into (mixed with) drugs such as heroin or cocaine. This type of fentanyl is usually sold as another substance, so people swallow, snort or inject it without realizing. Many overdoses have occurred because people did not know that what they were taking was contaminated with.

If you or someone you know uses opioids, it is a good idea to have a free naloxone kit.  Naloxone is a medication that can temporarily reverse the effects of an opioid overdose and allow time for medical help to arrive.

How does it make you feel?

When they’re used properly to treat pain, opioids reduce pain and the emotional response to pain. However, when they are misused, they may produce:

  • euphoria
  • drowsiness
  • relaxation
  • difficulty concentrating
  • constricted pupils
  • slowed breathing
  • nausea
  • vomiting
  • constipation
  • loss of appetite
  • sweating
  • overdose.

When someone overdoses on this medication, they first become sleepy, and it is hard to wake them. Their breathing becomes slow and shallow. They may snore, and they may pass out.

The person’s body may become limp, their face pale or clammy, and their pulse weak or slow. For lighter-skinned people, the lips and finger tips may turn blue or purple. For darker-skinned people, the inside of the lips may become blue or purple.


If someone is overdosing, call 911 right away! While you are waiting for medical help to arrive, you can use your naloxone kit to temporarily reverse the effects of the overdose.

The Good Samaritan Drug Overdose Act protects you from being charged or convicted for drug possession if you call 911 to report an overdose, or if you are at the scene when emergency services arrive. This is true even if you are on probation for possession.

Is it dangerous?

  • It is often impossible to tell if a powder or pill contains this medicine. You can’t see it, smell it or taste it. Even your dealer might not know what they are selling or how strong it is.
  • Because it is so strong, the difference between a dose that will get you high and a dose that can kill you is very small.
  • You can overdose even if you use someone’s prescription patch and know the dose. Everyone handles Duragesic differently. One person’s dose can kill another person.
  • If you are using other drugs at the same time—for example, other opioids, alcohol or sedatives such as Xanax, Valium or Ativan—the risk of overdose is even higher.


Do You Know. . . Prescription Opioids © 2012 Centre for Addiction and Mental Health
Straight Talk: Street Duragesic© 2017 Centre for Addiction and Mental Health
About opioids © 2017 Government of Canada
Opioid crisis in Canada © 2018 Government of Canada
What is Duragesic? © 2017 Royal Canadian Mounted Police


Where can I find help, treatment and support?

  • Treatment at CAMH: Access CAMH
  • Help for families from CAMH
  • ConnexOntario
  • Kids Help Phone at 1 800 668-6868
  • The Works Toronto, for harm reduction support and supplies.


Where can I find more information?

  • A free tutorial on addictions is available on the Mental Health 101 page.
  • Addiction: An Information Guide (PDF)
  • Straight talk: Street Fentora(PDF)
What is it called in the US?
In its prescription form, fentanyl is known by such names as Actiq®, Duragesic®, and Sublimaze®. Synthetic opioids, including Fentora, are now the most common drugs involved in drug overdose deaths in the United States.

Fentora | Duragesic | Subsys | Actiq 

COMMON USES: It is used to manage pain. This drug is not for mild pain or pain that only lasts a short time (like headaches, toothaches, or pain after surgery).This drug is only for use by people who have been taking pain drugs (op…


  • Actiq 600mcg Transmucosal


  • Duragesic 100mcg/hr Patch
  • Duragesic 12mcg/hr Patch
  • Duragesic 25mcg/hr Patch
  • Duragesic 50mcg/hr Patch


  • Fentora 100mcg Buccal Tablets
  • Fentora 200mcg Buccal Tablets
  • Fentora 400mcg Buccal Tablets
  • Fentora 600mcg Buccal Tablets
  • Fentora 800mcg Buccal Tablets


  • Subsys 100mcg Spray (blue Box) 10s
  • Subsys 1200mcg Spray
  • Subsys 1600mcg Spray
  • Subsys 200mcg Spray (green Box) 30s
  • Subsys 400mcg Spray (pink Box) 30s
  • Subsys 600mcg Spray (purple Box)30s


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