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Morphine | Oramorph | Analgesics


Morphine 15mg is an opioid medicine prescribed for severe pain when other pain-relief medicines are not effective or cannot be used. If you take morphine regularly, stopping suddenly can cause withdrawal symptoms. Always take Oramorph exactly as prescribed by your doctor.


Oramorph is a strong opiate that is found naturally in opium, a dark brown resin produced by drying the latex of opium poppies. It is mainly used as an analgesic. Wikipedia

Pregnancy category: : AU: C;
Metabolism: Liver: UGT2B7
Metabolites: • Oramorph -3-glucuronide (90%); • Morphine-6-glucuronide (10%)
Duration of action: 3–7 hours
Excretion: Kidney 90%, bile duct 10%
Formula: C₁₇H₁₉NO₃
IUPAC ID: (4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol


Oramorph is a highly addictive substance. Numerous studies, including one by The Lancet, ranked Oramorph /Heroin as #1 most addictive substance, followed by Cocaine at #2, Nicotine #3, followed by Barbiturates at 4 and ethanol at 5. In controlled studies comparing the physiological and subjective effects of heroin and in individuals formerly addicted to opiates, subjects showed no preference for one drug over the other. Equipotent, injected doses had comparable action courses, with diacetyl Oramorph crossing the BBB slightly quicker.

No difference in subjects’ self-rated feelings of euphoria, ambition, nervousness, relaxation, drowsiness, or sleepiness.[42] Short-term addiction studies by the same researchers demonstrated that tolerance developed at a similar rate to both heroin and it . When compared to the opioids hydro, fentanyl, oxycodone, and pethidine/meperidine, former addicts showed a strong preference for heroin and the med, suggesting that heroin and the MED are particularly susceptible to abuse and addiction. The Med and heroin also produced higher rates of euphoria and other positive subjective effects when compared to these other opioids.[42]

The choice of heroin and over other opioids by former drug addicts may also be because heroin (also known as diacetate, dia , or diacetyl is an ester of it and a morphine prodrug, essentially meaning they are identical drugs in vivo. Heroin is converted to this med before binding to the opioid receptors in the brain and spinal cord, where this medication causes the subjective effects, which is what the addicted individuals are seeking.[43]


Several hypotheses are given about how tolerance develops, including opioid receptor phosphorylation (which would change the receptor conformation), functional decoupling of receptors from G-proteins (leading to receptor desensitization),[44] μ-opioid receptor internalization or receptor down-regulation (reducing the number of available receptors for this med to act on), and upregulation of the cAMP pathway (a counterregulatory mechanism to opioid effects) (For a review of these processes, see Koch and Hollt.[45])

Dependence and withdrawal


Morphine is used to relieve moderate to severe pain. Belongs to a class of drugs known as opioid analgesics. It works in the brain to change how your body feels and responds to pain. Read the Medication Guide provided by your pharmacist before you start taking and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor. You may take this drug with or without food. If you have nausea, it may help to take this drug with food. Ask your doctor or pharmacist about other ways to decrease nausea (such as lying down for 1 to 2 hours with as little head movement as possible).

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Ask your pharmacist or doctor if you are not sure how to check or measure the dose.

The dosage is based on your medical condition and response to treatment. Do not increase your dose, take the medication more often, or take it for a longer time than prescribed. Properly stop the medication when so directed.

Pain medications work best if they are used when the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

If you have ongoing pain (such as due to cancer), your doctor may direct you to also take long-acting opioid medications. In that case, this medication might be used for sudden (breakthrough) pain only as needed. Other pain relievers (such as acetaminophen, ibuprofen) may also be prescribed with this medication. Ask your doctor or pharmacist about using it safely with other drugs.

Suddenly stopping this medication may cause withdrawal, especially if you have used it for a long time or in high doses. To prevent withdrawal, your doctor may lower your dose slowly. Tell your doctor or pharmacist right away if you have any withdrawal symptoms such as restlessness, mental/mood changes (including anxiety, trouble sleeping, thoughts of suicide), watering eyes, runny nose, nausea, diarrhea, sweating, muscle aches, or sudden changes in behavior.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.

Tell your doctor if your pain does not get better or if it gets worse, or if you have any new pain.


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