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Oxycontin 80mg

$135.00$760.00

Oxycodone is the generic name for the brand-name medication OxyContin, which is a powerful prescription medication used to manage severe pain.

 

Buy Oxycontin Online | Oxycontin Online Pharmacy

Treat moderate and severe pain with Oxycontin  is an opioid agonist indicated for pain severe enough to require daily, around-the-clock, long-term treatment and for which alternative treatment options are inadequate in: • Adults; and • Opioid-tolerant  pediatric patients 11 years of age and older who are already receiving and tolerate a minimum daily opioid dose of at least 20 mg  oral form or its equivalent. 
(oxycodone hydrochloride) extended-release tablets is an opioid analgesic supplied in 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, and 80 mg tablets for oral administration. The tablet strengths describe the amount of oxycodone per tablet as the hydrochloride salt.

OxyContin 80 mg prolonged release tablets

Active Ingredient of oxycontin is:

oxycodone hydrochloride
Company:
Napp Pharmaceuticals LimitedSee contact details
ATC code:
N02AA05
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About Medicine

{healthcare_pro_orange}This information is for use by healthcare professionals

Where to Buy Oxycontin Online

  You are at the right Place to buy oxycontin online . We have the best pain meds and we also do fast and discrete delivery . We also make sure that you buy online, no script but  prescribed to you by our health care providers knowledgeable in use of potent opioids for management of chronic pain. Must swallow tablets intact. Do not cut, break, chew, crush, or dissolve tablets (risk of potentially fatal dose).

(DOSAGE AND ADMINISTRATION)

Must take tablets one at a time, with enough water to ensure complete swallowing immediately after placing in mouth.
OXYCONTIN online pharmacy 60 mg and 80 mg tablets, a single dose greater than 40 mg, or a total daily dose greater than 80 mg are only for use in patients in whom tolerance to an opioid of comparable potency has been established.
Do not abruptly discontinue it use .

SIDE EFFECTS

shallow breathing, slow heartbeat;
seizure (convulsions);
cold, clammy skin;
confusion;
severe weakness or dizziness; or
a feeling like you might pass out.
Common side effects may include:
nausea, vomiting, constipation, loss of appetite;
dizziness, headache, tired feeling;*
DESCRIPTION
Oxycodone hydrochloride is a white, crystalline, odorless powder readily soluble in water,
sparingly soluble in ethanol and nearly insoluble in ether.
The tablets are modified release tablets designed to provide delivery of
over 12 hours.
Its 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg1
and 80 mg tablets have been
reformulated, and comprise a matrix formulation with a hydrogelling property (i.e. particles or
whole tablets become highly viscous (gel-like) in water), intended to be crush-deterrent and to
reduce the rapid release of this medication upon accidental or intentional misuse.
The tablets have been heat-treated to increase the mechanical strength of the tablet.
The physical properties of the reformulated tablets were examined following an
extensive battery of physical manipulations. Beyond demonstrating that the reformulated tablets are harder to crush than another controlled release it formulation,
testing over the range of the reformulated tablets fragment sizes showed that some
of the controlled release properties were still retained. Hydrogelling properties continued to be demonstrated.
PHARMACOLOGY
Actions
It is a full opioid agonist with no antagonist properties whose principal therapeutic
action is analgesia. It has an affinity for kappa, mu and delta opiate receptors in the brain and
spinal cord. This med is similar to morphine in its action.
Other pharmacological actions of oxycodone are in the central nervous system (CNS: respiratory depression, antitussive,
anxiolytic, sedative and miosis), smooth muscle (constipation, reduction in gastric, biliary and
pancreatic secretions, spasm of sphincter of Oddi and transient elevations in serum amylase)
and cardiovascular system (release of histamine and/or peripheral vasodilatation, possibly
causing pruritus, flushing, red eyes, sweating and/or orthostatic hypotension).
This group of medicine may influence the hypothalamic-pituitary-adrenal or –gonadal axes. Some changes
that can be seen include an increase in serum prolactin and decreases in plasma cortisol and
testosterone. Clinical symptoms may manifest from these hormonal changes.
Pharmacokinetics
Absorption
Compared with morphine, which has an absolute bioavailability of approximately 30%,
it has a high absolute bioavailability of up to 87% following oral administration.
The mean apparent half-life of this tablets is 6.5 hours and steady-state is achieved in
about one day.
Release of oxycodone from this tablets is independent of pH under physiological
conditions.
OxyContin tablets have an oral bioavailability comparable with immediate release oral
form, but achieve maximal plasma concentrations at about three hours compared with 1-
1.5 hours for immediate release oral form. Peak and trough concentrations of oxycodone
from the tablets 10 mg administered 12-hourly are similar to those achieved from
immediate release oxycodone 5 mg administered 6-hourly.
Dose proportionality has been established for the 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg1
and 80mg tablet strengths for both peak plasma concentrations (Cmax) and extent of absorption
(AUC).
Recent fasted and fed studies for its 10, 40 and 80 mg tablets indicate that food has
no significant effect on the extent of absorption of oxycodone from this tablets.
INDICATIONS
The management of moderate to severe chronic pain unresponsive to non-narcotic analgesia.
CONTRAINDICATIONS
Hypersensitivity to this MED or to any of the constituents of OxyContin tablets, acute respiratory
depression, cor pulmonale, cardiac arrhythmias, acute asthma or other obstructive airways
disease, suspected mechanical gastrointestinal obstruction (e.g. bowel obstruction, strictures) or
any diseases/conditions that affect bowel transit (e.g. ileus of any type),
Suspected surgical abdomen, severe renal impairment (creatinine clearance < 10 mL/min), severe hepatic
impairment (refer to Special Risk Groups), delayed gastric emptying, acute alcoholism, brain
tumour, increased cerebrospinal or intracranial pressure, head injury (due to risk of raised
intracranial pressure), severe CNS depression, convulsive disorders,
Delirium tremens, hypercarbia, concurrent administration of monoamine oxidase inhibitors or within two weeks
of discontinuation of their use. Not recommended for pre-operative use or for the first 24 hours
post-operatively. Pregnancy.
CLINICAL TRIALS
A double-blind, placebo-controlled, fixed-dose, parallel group, two-week study was
conducted in 133 patients with persistent, moderate to severe pain, who were judged as
having inadequate pain control with their current therapy. In this study, the 20 mg
tablets, but not 10 mg tablets, was statistically significant in pain reduction compared with
placebo (text from OxyContin US Prescribing Information dated April 2013).
PRECAUTIONS
The major risk of opioid excess is respiratory depression, including subclinical respiratory
depression. As with all opioids, a reduction in dosage may be advisable in hypothyroidism.
Use with caution in dependent patients and in patients with hypotension, hypovolaemia,
diseases of the biliary tract, pancreatitis, inflammatory bowel disorders, prostatic hypertrophy,
adrenocortical insufficiency (Addison’s disease), toxic psychosis, chronic pulmonary, renal or
hepatic disease, myxoedema and debilitated elderly or infirm patients.
As with all opioid preparations, patients who are to undergo cordotomy or other pain-relieving surgical procedures
should not receive the  tablets for 24 hours before surgery. In the immediate pre-operative period, and any symptoms of opioid withdrawal, should be managed with short-acting
analgesic agents. If further treatment with this tablets is then indicated the dosage
should be adjusted to the new post-operative requirement.

 

How to use Oxycontin

This medication oxycontin is used to help relieve severe ongoing pain (such as due to cancer). Oxycodone belongs to a class of drugs known as opioid analgesics. It works in the brain to change how your body feels and responds to pain. The higher strengths of this drug (more than 40 milligrams per tablet) should be used only if you have been regularly taking moderate to large amounts of an opioid pain medication. These strengths may cause overdose (even death) if taken by a person who has not been regularly taking opioids. Do not use the extended-release form of it to relieve pain that is mild or that will go away in a few days. This medication is not for occasional (“as needed”) use.

Read the Medication Guide provided by your pharmacist before you start taking extended-release oxycodone and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication on a regular schedule as directed by your doctor, not as needed for sudden (breakthrough) pain. Take this drug with or without food, usually every 12 hours. If you have nausea, it may help to take this drug with food. Ask your doctor or pharmacist about other ways to decrease nausea (such as lying down for 1 to 2 hours with as little head movement as possible). If nausea lasts, see your doctor.

Swallow the tablets whole. Do not break, crush, chew, or dissolve the tablets. Doing so can release all of the drug at once, increasing the risk of overdose.

To lessen the chance of choking or having trouble swallowing the tablet, take only one a tablet at a time if your dose is for more than one tablet. Do not pre-soak, lick, or wet the tablet before placing it in your mouth. Be sure to drink enough water with each tablet to swallow it completely.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

The dosage is based on your medical condition and response to treatment. Do not increase your dose, take the medication more often, or take it for a longer time than prescribed. Properly stop the medication when so directed.

Before you start taking this medication, ask your doctor or pharmacist if you should stop or change how you use your other medication(s). Other pain relievers (such as acetaminophenibuprofen) may also be prescribed. Ask your doctor or pharmacist about using it safely with other drugs.

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